Critical role of extracellularly secreted neuronal pentraxin 1 in ischemic neuronal death
نویسندگان
چکیده
منابع مشابه
Overexpression of neuronal pentraxin 1 is involved in neuronal death evoked by low K(+) in cerebellar granule cells.
Mature cerebellar granule cells in culture die by a process that requires new RNA and protein synthesis when deprived of depolarizing concentrations of potassium. We investigated gene expression during the early phase of the cell death program evoked by potassium deprivation. Using a differential gene display technique, we isolated a cDNA that was increased by potassium deprivation. This cDNA w...
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Neonatal hypoxic-ischemic brain injury is a major cause of neurological disability and mortality. Its therapy will likely require a greater understanding of the discrete neurotoxic molecular mechanism(s) triggered by hypoxia-ischemia (HI). Here, we investigated the role of neuronal pentraxin 1 (NP1), a member of a newly recognized subfamily of "long pentraxins," in the HI injury cascade. Neonat...
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Objective(s): While traumatic brain injury (TBI) is a predisposing factor for development of post-traumatic epilepsy (PTE), the occurrence of seizures following brain trauma can infuriate adverse consequences of brain injury. However, the effect of seizures in epileptogenesis after mild TBI cannot yet be accurately confirmed. This study was designed to investigate the ...
متن کاملMechanisms of Ischemic Induced Neuronal Death and Ischemic Tolerance
Stroke is the second leading cause of death and the primary cause of disability in humans. The phenomenon of ischemic tolerance perfectly describes the quote: “What does not kill you makes you stronger.’’ Ischemic preor postconditioning is actually the strongest known procedure to prevent or reverse delayed neuronal death. It works specifically in sensitive vulnerable neuronal populations, whic...
متن کاملNeuronal pentraxin, a secreted protein with homology to acute phase proteins of the immune system
We have identified, by affinity chromatography, a binding protein for the snake venom toxin taipoxin. The sequence of this 47 kDa protein is unique, is characteristic of a secreted protein, and has homology to the acute phase proteins serum amyloid P protein and C-reactive protein of the pentraxin family. We have named this protein neuronal pentraxin (NP), as Northern analysis and in situ hybri...
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ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2014
ISSN: 1471-2202
DOI: 10.1186/s12868-014-0133-3